Marquette and Villanova both made their respective offensive runs on Wednesday night.
In the end, the Wildcats ran the Golden Eagles right off the court at the Pavilion in Villanova, Pa.
The 72-58 loss ended Marquette's three-game winning streak and soured a night when junior forward Christina Quaye scored her 1,000th career point.
"We're all very proud of her (Quaye's) accomplishment, but we wish we would have been able to accomplish it with a victory," said head coach Terri Mitchell. "We just didn't play with the energy needed to take one on the road."
After the Golden Eagles took an early lead, the Wildcats dropped in eight straight points en route to a 12-8 lead with 12:50 remaining in the first half.
Four minutes later, Quaye scored two straight baskets, reached the 1,000-point plateau and kept Marquette close, trailing 20-18.
Villanova went up by six, only to have senior guard Carolyn Kieger respond with five unanswered points.
Back and forth the two teams went, and at halftime the Golden Eagles were down by three.
The tug-of-war continued into the second half, but Marquette lost its footing more and more as time wound down.
"Every time we cut the lead and had the ball, we gave up a turnover and they went down and scored," Mitchell said. "It took the life out of us."
Villanova went on a 13-4 run to start the second half, but the Golden Eagles charged back with an 11-3 spurt of their own.
Quaye did all the scoring on that run and finished the game with 19 points.
More than halfway into the second half, Marquette trailed 46-42 but would come no closer. The Wildcats pulled away with a 14-3 run.
"Their style of play is a slow-down, half-court offense, and we slowed down to their tempo," Kieger said. "We didn't force our style of play."
That much is evident in the box score. The Golden Eagles attempted only five three-point shots and tallied only two fast-break points.
This from a squad that had averaged 13.9 three-point attempts per game heading into Wednesday night's affair.
"We weren't attacking as well as we should have," Kieger said. "The guards weren't looking to shoot. We got tentative."
For the game, Marquette shot 48 percent (24-of-50) from the floor and outrebounded Villanova 33-29.
But statistical triumphs were no consolation to Mitchell, especially with a quick turnaround before her team's next game.
"We have to execute much better," Mitchell said. "When we do, we score. We have to be consistent in our execution."
The Golden Eagles (13-5, 4-3 Big East) return home to take on Seton Hall (6-12, 3-4) on Saturday at 7 p.m. at the Al McGuire Center.